What role do hormones such as ghrelin, leptin and oestrogen play in weight loss and appetite?

We are pleased to welcome you to this discussion about the important role hormones such as ghrelin, leptin and others play in regulating appetite and managing weight. This is a fascinating subject for me as a dietician and nutritionist. I hope you will understand the importance of hormones in maintaining healthy weight after reading this.

Ghrelin and Leptin: Their importance

Two hormones, ghrelin and leptin, play a crucial role in the energy balance of our bodies. These hormones are responsible for the regulation of hunger and satiation signals. This directly influences our diet and weight.

Ghrelin stimulates the appetite. Ghrelin is released when your stomach becomes empty. This signals your brain that you should eat. Leptin suppresses the appetite. The fat cells produce leptin, which tells your brain that you have eaten enough food and need to stop.

An article published in International Journal of Obesity revealed that obese individuals tend to have low leptin levels and high ghrelin levels. This imbalance may lead to weight gain and overeating. Managing these hormones may help with weight loss.

The Hormone Regulation: Some Pointers

Adopting a healthy way of life is the best way to regulate these levels. The following are some key factors to consider:

Appetite Management and Weight Management: Possible Solutions

You can regulate your leptin and ghrelin levels with these practical tips:

Other Tips

It is better to eat smaller meals more frequently throughout the day than three larger ones. This will help keep ghrelin stable. Consuming your final meal at least 3 hours before going to bed can help prevent nighttime ghrelin surges.


Conclusion: Ghrelin, and leptin are important hormones in controlling appetite and managing weight. By balancing your hormones, you can regulate appetite and maintain healthy weight. Everyone is different, and the same thing may not work for you. It's crucial to find the balance that is right for you.